SSR3 Gene Summary [Human]
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | SSR3 |
| Official Name | signal sequence receptor subunit 3 [Source:HGNC Symbol;Acc:HGNC:11325] |
| Ensembl ID | ENSG00000114850 |
| Bio databases IDs | |
| Aliases | signal sequence receptor subunit 3, translocon-associated protein gamma |
| Synonyms | 0610038P07RIK, signal sequence receptor, gamma, Signal sequence receptor gamma subunit, signal sequence receptor subunit 3, Signal sequence receptor γ, signal sequence receptor, γ, Signal sequence receptor γ subunit, Translocon associated protein γ, TRAP-complex gamma subunit, TRAP-complex γ subunit, TRAPG, Trap gamma, Trap γ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Translocon-associated protein, gamma subunit (TRAP-gamma)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding