ZC3HAV1 Gene Summary [Human]
This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021]
Details
| Type | Protein Coding |
| Official Symbol | ZC3HAV1 |
| Official Name | zinc finger CCCH-type containing, antiviral 1 [Source:HGNC Symbol;Acc:HGNC:23721] |
| Ensembl ID | ENSG00000105939 |
| Bio databases IDs | |
| Aliases | zinc finger CCCH-type containing, antiviral 1, zinc finger antiviral protein, CCCH-type zinc finger antiviral protein |
| Synonyms | 1200014N16Rik, 2810482G21Rik, 2900058M19Rik, 9130009D18Rik, 9830115L13RIK, ARTD13, D6BWG1452E, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, zinc finger CCCH type, antiviral 1, zinc finger CCCH-type containing, antiviral 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZC3HAV1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in Deltex and TRIP12 homologues
- CAAX box
- Zinc-finger antiviral protein (ZAP) zinc finger domain 3
- DEAD/H-box RNA helicase binding
- Poly(ADP-ribose) polymerase catalytic domain
- WWE domain
- protein binding
- ADP_ribosyl
- identical protein binding
- Zap helix turn helix N-terminal domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- COVID-19
- colorectal cancer
- multiple sclerosis
- organismal death
- liver cancer
- primary biliary cirrhosis
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- colon cancer
role in cell
- activation in
- binding in
- proliferation
- replication in
- cell viability
- expression in
- migration
- growth
- cell focus formation by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Nucleus
- lysosome
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZC3HAV1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mRNA catabolic process
- positive regulation of type I interferon production
- innate immune response
- defense response to virus
- protein poly-ADP-ribosylation
- response to virus
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- cadherin binding
- NAD+ binding
- NAD+ ADP-ribosyltransferase activity