CLC Gene Summary [Human]
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLC |
| Official Name | Charcot-Leyden crystal galectin [Source:HGNC Symbol;Acc:HGNC:2014] |
| Ensembl ID | ENSG00000105205 |
| Bio databases IDs | |
| Aliases | Charcot-Leyden crystal galectin, eosinophil lysophospholipase, lysolecithin acylhydrolase, galectin 10, lectin, galactoside-binding, soluble, 10 |
| Synonyms | CHARCOT-LEYDEN CRYSTAL, Charcot-Leyden crystal galectin, CLCP, GAL10, LGALS10, LGALS10A, LPPL HUMAN |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysophospholipase
- enzyme
- protein binding
- cytokine IL-6 receptor binding domain 3
- GLECT
- identical protein binding
- cytokine IL-6 receptor binding domain 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eosinophilic esophagitis
- severe acute respiratory syndrome
role in cell
- response
- survival
- phosphorylation in
- production in
- proliferation
- activity
- apoptosis
- anergy
- proliferative capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- granules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell anergy
- regulation of T cell cytokine production
- T cell apoptotic process
- regulation of activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- identical protein binding
- protein binding
- carbohydrate binding
- cysteine-type endopeptidase activity involved in apoptotic process