ZNRF4 Gene Summary [Human]
Predicted to enable ubiquitin protein ligase activity. Involved in ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNRF4 |
| Official Name | zinc and ring finger 4 [Source:HGNC Symbol;Acc:HGNC:17726] |
| Ensembl ID | ENSG00000105428 |
| Bio databases IDs | |
| Aliases | zinc and ring finger 4, sperizin, nixin |
| Synonyms | 1700094M01Rik, LOC148066, RNF204, SPERIZIN, spzn, Ssrzf1, Tisp69, zinc and ring finger 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNRF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- PA
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNRF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of cell cycle
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding