GRAMD1A Gene Summary [Human]
Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Located in cytosol; organelle membrane contact site; and plasma membrane. Is extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GRAMD1A |
| Official Name | GRAM domain containing 1A [Source:HGNC Symbol;Acc:HGNC:29305] |
| Ensembl ID | ENSG00000089351 |
| Bio databases IDs | |
| Aliases | GRAM domain containing 1A |
| Synonyms | 1300003M23Rik, D7Bwg0611e, Eg1rvc, GRAM domain containing 1A, KIAA1533, RGD1311022 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRAMD1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- cholesterol binding
- protein binding
- Pleckstrin homology-like domain
- VAD1 Analog of StAR-related lipid transfer domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rotator cuff injury
- survival
- systemic juvenile idiopathic arthritis
regulated by
- HuH7 cells
- PKD1
role in cell
- expression in
- molecular cleavage in
- proliferation
- accumulation in
- response by
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- endoplasmic reticulum membrane
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRAMD1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- cellular response to cholesterol
- intracellular sterol transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- organelle membrane contact site
- cytosol
- cytoplasmic vesicle
- autophagic vacuole
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding