FGF21
FGF21 Gene Summary
Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | FGF21 |
| Official Name | fibroblast growth factor 21 [Source:HGNC Symbol;Acc:HGNC:3678] |
| Ensembl ID | ENSG00000105550 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 21 |
| Synonyms | Fgf8c,fibroblast growth factor 21 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the FGF21 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PPARA
- ELAVL1
- CASP6
- FGFR1
- ARNT
- FGFR4
- NEDD4
- NR4A1
- DNALI1
- SGTA
disease
- weight gain
- neoplasia
- edema
- impaired glucose tolerance
- insulin resistance
- hepatic steatosis
- skin wrinkling
- hypoketonemia
- weight loss
- luminal B breast cancer
regulated by
- curcumin
- PPARA
- PPARGC1A
- TGFB1
- OPA1
- GCG
- INS
- D-glucose
- cinnamaldehyde
- pirinixic acid
regulates
- PPARA
- AKT
- MMP2
- IL6
- ERK
- ERK1/2
- CCL2
- TGFB1
- AVP
- MMP9
role in cell
- expression in
- proliferation
- cellular infiltration by
- quantity
- accumulation in
- phosphorylation in
- apoptosis
- binding
- activation in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FGF21 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
- endoplasmic reticulum unfolded protein response
- cellular response to glucose stimulus
- cellular response to glucagon stimulus
- positive regulation of triglyceride catabolic process
- negative regulation of endothelial cell apoptotic process
- signal transduction
- cell-cell signaling
- positive regulation of glucose import
- positive regulation of MAPK cascade
- organ morphogenesis
- regulation of low-density lipoprotein particle clearance
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
- cellular response to xenobiotic stimulus
- response to activity
- endothelial cell apoptotic process
- regulation of cell migration
- response to nutrient levels
- cellular response to low-density lipoprotein particle stimulus
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding