Fgf21 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; cerebellum; hemolymphoid system; and musculoskeletal system. Orthologous to human FGF21 (fibroblast growth factor 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf21 |
| Official Name | fibroblast growth factor 21 [Source:MGI Symbol;Acc:MGI:1861377] |
| Ensembl ID | ENSMUSG00000030827 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 21 |
| Synonyms | Fgf8c, fibroblast growth factor 21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- neoplasia
- edema
- impaired glucose tolerance
- insulin resistance
- hepatic steatosis
- skin wrinkling
- hypoketonemia
- weight loss
- luminal B breast cancer
phenotypes
- abnormal adipose tissue morphology
- abnormal blood homeostasis
- abnormal body weight
- abnormal brown adipose tissue physiology
- abnormal brown adipose tissue thermogenesis
- abnormal brown fat cell morphology
- abnormal circulating free fatty acids level
- abnormal food intake
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal hypothalamus secretion
- abnormal lipid homeostasis
- abnormal lipid level
- abnormal liver physiology
- abnormal white adipose tissue physiology
- abnormal white fat cell size
- decreased body temperature
- decreased circulating free fatty acid level
- decreased circulating glucose level
- decreased circulating growth hormone level
- decreased circulating insulin-like growth factor I level
- decreased circulating ketone body level
- decreased fatty acid level
- decreased oxygen consumption
- decreased physiological sensitivity to xenobiotic
- decreased white adipose tissue amount
- decreased white fat cell size
- enhanced lipolysis
- hepatic steatosis
- hypoactivity
- hypoglycemia
- impaired adaptive thermogenesis
- impaired glucose tolerance
- impaired lipolysis
- increased body length
- increased body weight
- increased brown adipose tissue amount
- increased circulating cholesterol level
- increased circulating free fatty acid level
- increased circulating glucose level
- increased circulating growth hormone level
- increased circulating insulin level
- increased circulating ketone body level
- increased circulating leptin level
- increased circulating triglyceride level
- increased creatine kinase activity
- increased gonadal fat pad weight
- increased lean body mass
- increased liver glycogen level
- increased liver triglyceride level
- increased liver weight
- increased long bone epiphyseal plate size
- increased total body fat amount
- increased white adipose tissue amount
- increased white fat cell size
- increased width of hypertrophic chondrocyte zone
- long tibia
- no abnormal phenotype detected
role in cell
- expression in
- proliferation
- cellular infiltration by
- quantity
- accumulation in
- phosphorylation in
- apoptosis
- binding
- activation in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
- endoplasmic reticulum unfolded protein response
- cellular response to glucose stimulus
- cellular response to glucagon stimulus
- positive regulation of triglyceride catabolic process
- negative regulation of endothelial cell apoptotic process
- signal transduction
- cell-cell signaling
- positive regulation of glucose import
- positive regulation of MAPK cascade
- organ morphogenesis
- regulation of low-density lipoprotein particle clearance
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
- cellular response to xenobiotic stimulus
- response to activity
- endothelial cell apoptotic process
- regulation of cell migration
- response to nutrient levels
- cellular response to low-density lipoprotein particle stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding