NR4A1 Gene Summary [Human]
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | NR4A1 |
| Official Name | nuclear receptor subfamily 4 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7980] |
| Ensembl ID | ENSG00000123358 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 4 group A member 1 |
| Synonyms | Gfrp, GFRP1, Hbr-1, HMR, N10, NAK-1, NGFI-B, NP10, nuclear receptor subfamily 4 group A member 1, nuclear receptor subfamily 4, group A, member 1, NUR77, NUR77-1, NUR77-2, NURA, TIS1, TR3, TR3 ORPHAN receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR4A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- ligand-dependent nuclear receptor interactor
- transcription regulator
- amphipathic helix
- DNA binding domain
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- A/B region
- transcription activation domain
- AF-2 transcription activation domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- lipopolysaccharide binding
- DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- DE domain
- AF-1 domain
- ligand-binding domain
- double-stranded DNA binding
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
- protein heterodimerization
Pathways
Biological processes and signaling networks where the NR4A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- neurological disorder
- cancer
- weight gain
- uterine leiomyoma
- leiomyomatosis
- endometriosis
- osteoarthritis
- primary biliary cirrhosis
role in cell
- phosphorylation in
- production in
- cell death
- activation in
- formation in
- expression in
- apoptosis
- binding
- survival
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial outer membrane
- nucleoplasm
- nuclear envelope
- nuclear speckles
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR4A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter secretion involved in regulation of skeletal muscle contraction
- signal transduction
- negative regulation of cell cycle
- cellular response to fibroblast growth factor stimulus
- transcription from RNA polymerase II promoter
- cell migration involved in sprouting angiogenesis
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- inflammatory response
- skeletal muscle cell differentiation
- response to amphetamine
- cellular response to corticotropin-releasing hormone stimulus
- apoptotic process
- positive regulation of apoptotic process
- endothelial cell chemotaxis
- cellular response to vascular endothelial growth factor stimulus
- positive regulation of endothelial cell proliferation
- detection of lipopolysaccharide
- response to electrical stimulus
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nuclear membrane
- mitochondrion
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- identical protein binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- glucocorticoid receptor binding
- lipopolysaccharide binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity