LSR Gene Summary [Human]
Predicted to be involved in several processes, including establishment of skin barrier; protein localization to tricellular tight junction; and tricellular tight junction assembly. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | LSR |
| Official Name | lipolysis stimulated lipoprotein receptor [Source:HGNC Symbol;Acc:HGNC:29572] |
| Ensembl ID | ENSG00000105699 |
| Bio databases IDs | |
| Aliases | lipolysis stimulated lipoprotein receptor, lipolysis-stimulated remnant, immunoglobulin-like domain containing receptor 3, angulin-1 |
| Synonyms | ILDR3, lipolysis stimulated lipoprotein receptor, LISCH7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LSR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- transcription regulator
- fatty acid binding
- lipoprotein receptor
- protein binding
- low-density lipoprotein binding
- triglyceride binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- experimental autoimmune encephalomyelitis
- breast cancer
- aldosterone producing adrenocortical adenoma
- hypoplasia
- dermatological disorder
- bleeding
- experimental stroke
- hyperlipidemia
regulates
- triacylglycerol
- LDL
- lipid
- 1,1'-didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate
- 1,2-cyclohexanedione
- VLDL
- LIPOPROTEIN
- cholesterol
- lipoprotein
- phospholipid
role in cell
- binding
- internalization by
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- cell junction
- cellular membrane
- Plasma Membrane
- Mitochondria
- intercellular junctions
- tricellular junction
- bicellular junction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LSR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial structure maintenance
- liver development
- establishment of blood-brain barrier
- maintenance of blood-brain barrier
- establishment of skin barrier
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- tight junction
- occluding junction
- chylomicron
- extracellular vesicular exosome
- low-density lipoprotein particle
- cell junction
- plasma membrane