Lsr Gene Summary [Mouse]
Predicted to enable lipoprotein particle receptor activity and low-density lipoprotein particle binding activity. Involved in several processes, including establishment of skin barrier; protein localization to tricellular tight junction; and tricellular tight junction assembly. Located in plasma membrane and tricellular tight junction. Is expressed in several structures, including alimentary system; genitourinary system; limb; liver; and respiratory system. Orthologous to human LSR (lipolysis stimulated lipoprotein receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lsr |
| Official Name | lipolysis stimulated lipoprotein receptor [Source:MGI Symbol;Acc:MGI:1927471] |
| Ensembl ID | ENSMUSG00000001247 |
| Bio databases IDs | |
| Aliases | lipolysis stimulated lipoprotein receptor |
| Synonyms | ILDR3, lipolysis stimulated lipoprotein receptor, LISCH7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lsr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- transcription regulator
- fatty acid binding
- lipoprotein receptor
- protein binding
- low-density lipoprotein binding
- triglyceride binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- experimental autoimmune encephalomyelitis
- breast cancer
- aldosterone producing adrenocortical adenoma
- hypoplasia
- dermatological disorder
- bleeding
- experimental stroke
- hyperlipidemia
regulates
- triacylglycerol
- LDL
- lipid
- 1,1'-didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate
- 1,2-cyclohexanedione
- VLDL
- LIPOPROTEIN
- cholesterol
- lipoprotein
- phospholipid
role in cell
- binding
- internalization by
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- cell junction
- cellular membrane
- Plasma Membrane
- Mitochondria
- intercellular junctions
- tricellular junction
- bicellular junction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lsr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial structure maintenance
- liver development
- establishment of blood-brain barrier
- maintenance of blood-brain barrier
- establishment of skin barrier
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- tight junction
- occluding junction
- chylomicron
- extracellular vesicular exosome
- low-density lipoprotein particle
- cell junction
- plasma membrane