SSBP1 Gene Summary [Human]
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | SSBP1 |
| Official Name | single stranded DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11317] |
| Ensembl ID | ENSG00000106028 |
| Bio databases IDs | |
| Aliases | single stranded DNA binding protein 1 |
| Synonyms | 2810480P10Rik, G630031O20RIK, mtDBP, Mt-SSB, OPA13, SINGLE STRANDED DNA binding, single-stranded DNA binding protein 1, Single Stranded DNA Binding Protein, mitochondrial precursor, SOSS-B1, SSBP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- protein homodimerization
- chromatin binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- breast cancer
- optic atrophy 13 with retinal and foveal abnormalities
- Leigh syndrome
- lung metastasis
- organismal death
- gout
- glioblastoma cancer
- cone-rod dystrophy
role in cell
- expression in
- growth
- transmembrane potential
- proliferation
- migration
- invasion by
- consumption in
- organization
- temozolomide sensitivity
- epithelial-mesenchymal transition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cellular membrane
- Nucleus
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- positive regulation of helicase activity
- positive regulation of mitochondrial DNA replication
- mitochondrial DNA replication
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- RNA binding
- protein binding
- chromatin binding
- single-stranded DNA binding