Ssbp1 Gene Summary [Mouse]
Predicted to enable several functions, including chromatin binding activity; protein homodimerization activity; and single-stranded DNA binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in brain ventricular layer; foregut; renal cortex; and submandibular gland primordium. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human SSBP1 (single stranded DNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ssbp1 |
| Official Name | single-stranded DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:1920040] |
| Ensembl ID | ENSMUSG00000029911 |
| Bio databases IDs | |
| Aliases | single-stranded DNA binding protein 1 |
| Synonyms | 2810480P10Rik, G630031O20RIK, mtDBP, Mt-SSB, OPA13, SINGLE STRANDED DNA binding, single-stranded DNA binding protein 1, Single Stranded DNA Binding Protein, mitochondrial precursor, SOSS-B1, SSBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ssbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- protein homodimerization
- chromatin binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- breast cancer
- optic atrophy 13 with retinal and foveal abnormalities
- Leigh syndrome
- lung metastasis
- organismal death
- gout
- glioblastoma cancer
- cone-rod dystrophy
role in cell
- expression in
- growth
- transmembrane potential
- proliferation
- migration
- invasion by
- consumption in
- organization
- temozolomide sensitivity
- epithelial-mesenchymal transition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cellular membrane
- Nucleus
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ssbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- positive regulation of helicase activity
- positive regulation of mitochondrial DNA replication
- mitochondrial DNA replication
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- RNA binding
- protein binding
- chromatin binding
- single-stranded DNA binding