TARS2 Gene Summary [Human]
This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | TARS2 |
| Official Name | threonyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:30740] |
| Ensembl ID | ENSG00000143374 |
| Bio databases IDs | |
| Aliases | threonyl-tRNA synthetase 2, mitochondrial, threonine tRNA ligase 2, mitochondrial |
| Synonyms | 2610024N01Rik, COXPD21, RGD1308283, TARSL1, threonyl-tRNA synthetase 2, mitochondrial, threonyl-tRNA synthetase 2, mitochondrial (putative), thrRS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TARS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- threonine-tRNA ligase
- tRNA synthetase class II core domain (G, H, P, S and T)
- HGTP_anticodon
- threonyl-tRNA synthetase
- TGS domain
- class_II_aaRS-like_core
- Anticodon binding domain
- Ubl1_cv_Nsp3_N-like
- protein homodimerization
- Threonyl and Alanyl tRNA synthetase second additional domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- combined oxidative phosphorylation deficiency 21
- Leigh syndrome
- systolic dysfunction
role in cell
- growth
- phosphorylation in
- survival
- morphology
- number
- G2/M phase
- respiration in
- Gap 0-Gap 1 phase
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TARS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial threonyl-tRNA aminoacylation
- threonyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein homodimerization activity
- aminoacyl-tRNA editing activity
- threonine-tRNA ligase activity