ABI3 Gene Summary [Human]
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | ABI3 |
| Official Name | ABI family member 3 [Source:HGNC Symbol;Acc:HGNC:29859] |
| Ensembl ID | ENSG00000108798 |
| Bio databases IDs | |
| Aliases | ABI family member 3 |
| Synonyms | 2210414K06Rik, ABI family member 3, ABI family, member 3, NESH, SSH3BP3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ABI3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Abl-interactor HHR
- protein binding
- identical protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- intracellular space
- postsynaptic region
- dendritic spines
- cell membrane leading edge
- postsynaptic density
- dendritic shafts
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ABI3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- peptidyl-tyrosine phosphorylation
- defense response to tumor cell
- neuron migration
- negative regulation of lamellipodium assembly
- positive regulation of cellular senescence
- regulation of cell migration
- negative regulation of ruffle assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- SCAR complex
- cytoplasm
- dendritic shaft
- dendritic spine
- membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- identical protein binding
- protein binding
- signaling adaptor activity
- SH3 domain binding