PAK2 Gene Summary [Human]
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PAK2 |
| Official Name | p21 (RAC1) activated kinase 2 [Source:HGNC Symbol;Acc:HGNC:8591] |
| Ensembl ID | ENSG00000180370 |
| Bio databases IDs | |
| Aliases | p21 (RAC1) activated kinase 2, S6/H4 kinase |
| Synonyms | 5330420P17RIK, A130002K10Rik, D16Ertd269e, gamma-PAK, KNO2, LOC100910732, mKIAA4182, p21 activated protein kinase γ, p21 (RAC1) activated kinase 2, PAK65, PAKgamma, PAK γ, γ-PAK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- regulatory domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- protein binding
- Protein kinase domain
- identical protein binding
- Nck-binding domain
- protein tyrosine kinase activator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- CRIB
- alcohol group acceptor phosphotransferase
- PIX binding domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the PAK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- CCR3 Signaling in Eosinophils
- CXCR4 Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- ErbB Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- IL-8 Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- Natural Killer Cell Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Renal Cell Carcinoma Signaling
- Renin-Angiotensin Signaling
- Semaphorin Signaling in Neurons
- TNFR1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lymphomagenesis
- Alzheimer disease
- cancer
- schizophrenia
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- growth failure
role in cell
- apoptosis
- survival
- activation in
- cell death
- phosphorylation in
- expression in
- proliferation
- migration
- binding in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- focal adhesions
- Nucleus
- Plasma Membrane
- intercellular junctions
- cytosol
- proplatelets
- membrane ruffles
- nucleoplasm
- nuclear speckles
- secretory granules
- cell membrane leading edge
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
- protein autophosphorylation
- protein phosphorylation
- negative regulation of protein kinase activity
- stimulatory C-type lectin receptor signaling pathway
- regulation of axonogenesis
- apoptotic process
- phosphorylation
- intracellular signal transduction
- positive regulation of peptidyl-tyrosine phosphorylation
- signal transduction
- dendritic spine development
- cardiac muscle hypertrophy
- cellular response to transforming growth factor beta stimulus
- negative regulation of stress fiber assembly
- vascular endothelial growth factor receptor signaling pathway
- regulation of cytoskeleton organization
- negative regulation of apoptotic process
- tight junction assembly
- positive regulation of extrinsic apoptotic signaling pathway
- adherens junction assembly
- peptidyl-serine phosphorylation
- cellular response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- cell-cell junction
- perinuclear region of cytoplasm
- cytoplasm
- secretory granule
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- identical protein binding
- protein binding
- cadherin binding
- protein tyrosine kinase activator activity
- small GTPase binding
- protein kinase activity
- protein serine/threonine kinase activity