DESI1 Gene Summary [Human]
Enables importin-alpha family protein binding activity. Involved in protein export from nucleus and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DESI1 |
| Official Name | desumoylating isopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:24577] |
| Ensembl ID | ENSG00000100418 |
| Bio databases IDs | |
| Aliases | desumoylating isopeptidase 1, polyubiquitinated substrate transporter |
| Synonyms | CLONE RP3-347H13, D15Wsu75e, DESI2, desumoylating isopeptidase 1, DJ347H13.4, FAM152B, POST, PPPDE2, RGD1305776 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DESI1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO-specific protease
- peptidase
- PPPDE putative peptidase domain
- protein binding
- identical protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DESI1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein desumoylation
- proteolysis
- protein export from nucleus
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein modification by small protein removal
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- palmitoyl-(protein) hydrolase activity
- long-chain acyl-CoA hydrolase activity
- SUMO-specific protease activity