SULT1E1 Gene Summary [Human]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
SULT1E1
Official Name
sulfotransferase family 1E member 1 [Source:HGNC Symbol;Acc:HGNC:11377]
Ensembl ID
ENSG00000109193
Bio databases IDs NCBI: 6783 Ensembl: ENSG00000109193
Aliases sulfotransferase family 1E member 1
Synonyms EST, EST-1, estrogen sulphotransferase, ST1D, ST1E1, ST1E4, STE, sulfotransferase family 1E member 1, sulphotransferase family 1E member 1
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SULT1E1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • sulfotransferase
  • steroid sulfotransferase
  • estrone sulfotransferase
  • Sulfotransferase domain
  • enzyme
  • protein binding
  • flavonol 3-sulfotransferase

Pathways

Biological processes and signaling networks where the SULT1E1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • hepatocellular carcinoma
  • liver cancer
  • non-insulin-dependent diabetes mellitus
  • experimental hepatitis
  • hepatic steatosis
  • acute lung injury
regulated by
  • progesterone
  • estrogen
  • MRTFA
  • MRTFB
  • NR1H4
  • EWSR1-FLI1
  • stromal cells
  • turofexorate isopropyl
  • HNF4A
  • butyric acid
regulates
role in cell
  • differentiation
  • proliferation
  • infiltration by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol
  • nuclear envelope

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SULT1E1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • estrogen metabolic process
  • ethanol catabolic process
  • steroid metabolic process
  • 3'-phosphoadenosine 5'-phosphosulfate metabolic process
  • positive regulation of fat cell differentiation
  • sulfation
  • estrogen catabolic process

Cellular Component

Where in the cell the gene product is active
  • nuclear membrane
  • cytoplasm
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • estrone sulfotransferase activity
  • protein binding
  • steroid sulfotransferase activity
  • flavonol 3-sulfotransferase activity
  • aryl sulfotransferase activity
  • sulfotransferase activity
  • steroid binding

Gene-Specific Assays for Results You Can Trust

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