ENOX1 Gene Summary [Human]
The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | ENOX1 |
| Official Name | ecto-NOX disulfide-thiol exchanger 1 [Source:HGNC Symbol;Acc:HGNC:25474] |
| Ensembl ID | ENSG00000120658 |
| Bio databases IDs | |
| Aliases | ecto-NOX disulfide-thiol exchanger 1, ecto-NADPH oxidase disulfide-thiol exchanger 1 |
| Synonyms | B230207J08, bA64J21.1, cCNOX, CNOX, D230005D02Rik, ecto-NOX disulfide-thiol exchanger 1, LOC100363621, LOC684954, PIG38, RGD1306118 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENOX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- NADH2 dehydrogenase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the ENOX1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENOX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ultradian rhythm
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein disulfide isomerase activity
- NADH dehydrogenase activity
- RNA binding