PDE9A Gene Summary [Human]
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PDE9A |
| Official Name | phosphodiesterase 9A [Source:HGNC Symbol;Acc:HGNC:8795] |
| Ensembl ID | ENSG00000160191 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 9A |
| Synonyms | HSPDE9A2, LOC100132338, PDE9A1, phosphodiesterase-9, phosphodiesterase 9A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDE9A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- 3',5'-cyclic-GMP phosphodiesterase
- enzyme
- protein binding
- HDc
- identical protein binding
- 3',5'-cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the PDE9A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- prostate cancer
- idiopathic pulmonary fibrosis
- pulmonary hypertension
- heart disease
- pulmonary hypertensive arterial disease
- schizophrenia
- sexual disorder
- major depression
- coronary artery disease
regulates
- cyclic GMP
role in cell
- proliferation
- cell death
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- sarcolemma
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDE9A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP metabolic process
- cGMP catabolic process
- signal transduction
- positive regulation of long-term synaptic potentiation
- negative regulation of neural precursor cell proliferation
- positive regulation of cardiac muscle hypertrophy
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- sarcolemma
- ruffle membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- perikaryon
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity