CXCR3 Gene Summary [Human]
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | CXCR3 |
| Official Name | C-X-C motif chemokine receptor 3 [Source:HGNC Symbol;Acc:HGNC:4540] |
| Ensembl ID | ENSG00000186810 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine receptor 3 |
| Synonyms | CD182, CD183, CKR-L2, CMKAR3, C-X-C motif chemokine receptor 3, GPR9, IP10-R, Mig-R, TAC, Zonulin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CXCR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- chemokine binding
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- chemokine receptor binding domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- C-X-C chemokine binding
- C-X-C chemokine receptor
- chemokine receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the CXCR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- epithelial cancer
- lung carcinoma process
- lung cancer
- thoracic cancer
- epithelial neoplasia
- cancer
role in cell
- growth
- expression in
- proliferation
- cellular infiltration by
- phosphorylation in
- survival
- apoptosis
- activation
- aggregation
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- endosomes
- lysosome
- plasma membrane extracellular face
- endolysosomes
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CXCR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- cell adhesion
- elevation of cytosolic calcium ion concentration
- regulation of leukocyte migration
- cell chemotaxis
- chemotaxis
- inflammatory response
- immune response
- angiogenesis
- chemokine-mediated signaling pathway
- apoptotic process
- regulation of cell adhesion
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- chemokine binding
- protein binding
- C-C chemokine receptor activity
- C-X-C chemokine receptor activity
- chemokine receptor activity