CCL26
CCL26 Gene Summary
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]
Details
| Type | Protein Coding |
| Official Symbol | CCL26 |
| Official Name | C-C motif chemokine ligand 26 [Source:HGNC Symbol;Acc:HGNC:10625] |
| Ensembl ID | ENSG00000006606 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 26, macrophage inflammatory protein 4-alpha, small inducible cytokine A26, CC chemokine IMAC, chemokine N1, thymic stroma chemokine-1, eotaxin-3 |
| Synonyms | Ccl26l,C-C motif chemokine ligand 26,IMAC,LOC687177,MIP-4a,MIP-4alpha,SCYA26,TSC-1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- chemokine receptor binding
- receptor agonist activity
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CCL26 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CXCL10
- CXCL11
- CCL11
- CXCL12
- ETV1
- CCL2
- CREBBP
- LGALS3
- PF4V1
- PF4
disease
- Crohn disease
- eosinophilic esophagitis
- mastocytosis
- COVID-19
- peroxisomal acyl CoA oxidase deficiency
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- pruritus
- ulcerative colitis
regulated by
- TNF
- lipopolysaccharide
- dexamethasone
- IL13
- ERK1/2
- STAT6
- p38 MAPK
- PPARD
- IL4
- TSC2
regulates
- Ca2+
- ATF2
- CREBBP
- RHEB
- CCR3
- GTPase
- CCL26
- CCL18
role in cell
- binding
- activation in
- proliferation
- migration
- activation
- recruitment
- chemotaxis
- polymerization
- shape change
- healing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Weibel-Palade bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CCL26 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- signal transduction
- cell-cell signaling
- positive regulation of GTPase activity
- chemotaxis
- inflammatory response
- T cell chemotaxis
- monocyte chemotaxis
- chemokine-mediated signaling pathway
- eosinophil chemotaxis
- positive regulation of actin filament polymerization
- positive regulation of endothelial cell proliferation
- positive regulation of chemotaxis
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
MOLECULAR FUNCTION
What the gene product does at the molecular level
- CX3C chemokine receptor binding
- CCR chemokine receptor binding
- protein binding
- CCR3 chemokine receptor binding
- receptor agonist activity
- chemokine activity