FOLR3 Gene Summary [Human]
This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | FOLR3 |
| Official Name | folate receptor gamma [Source:HGNC Symbol;Acc:HGNC:3795] |
| Ensembl ID | ENSG00000110203 |
| Bio databases IDs | |
| Aliases | folate receptor gamma |
| Synonyms | folate receptor gamma, folate receptor γ, FR-G, FR-gamma, FR-γ, gamma-hFR, γ-hFR |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOLR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- folic acid binding
- protein binding
- Folate receptor family
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- organelle lumens
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOLR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- folic acid transport
- sperm-egg recognition
- fusion of sperm to egg plasma membrane
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- membrane
- external side of plasma membrane
- extrinsic to membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- folic acid binding