FBXO2 Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | FBXO2 |
| Official Name | F-box protein 2 [Source:HGNC Symbol;Acc:HGNC:13581] |
| Ensembl ID | ENSG00000116661 |
| Bio databases IDs | |
| Aliases | F-box protein 2 |
| Synonyms | FBG1, F-box protein 2, Fbs1, Fbs2, FBX2, NFB42, OCP1, PRPL4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box associated region
- enzyme
- protein binding
- carbohydrate binding
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- neoplasia
- hearing loss
- organismal death
- age-related hearing loss
- cognitive impairment
role in cell
- apoptosis
- expression in
- migration
- proliferation
- invasion by
- degradation in
- degeneration
- abnormal morphology
- synaptic transmission
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic spine
- glutaminergic synapse
- somatodendritic region
- Nucleus
- Plasma Membrane
- cytosol
- dendritic spines
- axons
- dendrites
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- protein modification process
- negative regulation of cell proliferation
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- dendritic spine
- cytosol
- endoplasmic reticulum
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- carbohydrate binding
- denatured protein binding
- beta-amyloid binding