PSMD9
PSMD9 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | PSMD9 |
| Official Name | proteasome 26S subunit, non-ATPase 9 [Source:HGNC Symbol;Acc:HGNC:9567] |
| Ensembl ID | ENSG00000110801 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, non-ATPase 9 |
| Synonyms | 1500011J20Rik,2610202L11Rik,Bridge,Bridge-1,LOC103694906,P27,proteasome 26S subunit, non-ATPase 9,proteasome (prosome, macropain) 26S subunit, non-ATPase, 9,Rpn4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- Nas2 N_terminal domain
- transcription factor binding
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the PSMD9 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GABRA2
- RIN3
- KLKB1
- PSMC6
- SEC23IP
- RPS16
- LSM14B
- NCKIPSD
- PSMC4
- ZRANB1
disease
- acute myeloid leukemia
- major depression
regulated by
- INHBA
- metribolone
- EAhy926 cells
- ETV6-RUNX1
- SMYD3
- 5-methyltetrahydrofolic acid
- UBR2
- thioguanine nucleotide
- RAD51
- folic acid
regulates
- insulin
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- SMAD2
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- synaptosomes
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PSMD9 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- proteasome regulatory particle assembly
- negative regulation of insulin secretion
- positive regulation of insulin secretion
- ubiquitin-dependent protein catabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- cytoplasm
- proteasome regulatory particle
- cytosol
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- bHLH transcription factor binding