Psmd9 Gene Summary [Mouse]

Predicted to enable bHLH transcription factor binding activity and transcription coactivator activity. Predicted to be involved in several processes, including proteasome regulatory particle assembly; regulation of insulin secretion; and type B pancreatic cell apoptotic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cranium; genitourinary system; liver; lung; and sensory organ. Orthologous to human PSMD9 (proteasome 26S subunit, non-ATPase 9). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Processed Transcript
Official Symbol
Psmd9
Official Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 [Source:MGI Symbol;Acc:MGI:1914401]
Ensembl ID
ENSMUSG00000029440
Bio databases IDs NCBI: 67151 Ensembl: ENSMUSG00000029440
Aliases proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Synonyms 1500011J20Rik, 2610202L11Rik, Bridge, Bridge-1, LOC103694906, P27, proteasome 26S subunit, non-ATPase 9, proteasome (prosome, macropain) 26S subunit, non-ATPase, 9, Rpn4
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmd9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • transcription co-activator
  • Nas2 N_terminal domain
  • transcription factor binding
  • protein binding
  • PDZ domain
  • cpPDZ_Deg_HtrA-like
  • cpPDZ_RseP_YlbL-like

Pathways

Biological processes and signaling networks where the Psmd9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • acute myeloid leukemia
  • major depression
regulated by
  • INHBA
  • metribolone
  • EAhy926 cells
  • ETV6-RUNX1
  • SMYD3
  • 5-methyltetrahydrofolic acid
  • UBR2
  • thioguanine nucleotide
  • RAD51
  • folic acid
regulates
  • insulin
  • DNA promoter
  • DNA endogenous promoter
  • RNA polymerase II
  • SMAD2

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • cytosol
  • synaptosomes
  • clastosomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmd9 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of transcription, DNA-dependent
  • proteasome regulatory particle assembly
  • negative regulation of insulin secretion
  • positive regulation of insulin secretion
  • ubiquitin-dependent protein catabolic process

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • proteasome regulatory particle
  • cytosol
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • transcription coactivator activity
  • bHLH transcription factor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.