ITFG2 Gene Summary [Human]
Involved in cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Located in lysosomal membrane. Part of KICSTOR complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ITFG2 |
| Official Name | integrin alpha FG-GAP repeat containing 2 [Source:HGNC Symbol;Acc:HGNC:30879] |
| Ensembl ID | ENSG00000111203 |
| Bio databases IDs | |
| Aliases | integrin alpha FG-GAP repeat containing 2 |
| Synonyms | 2700050P07Rik, FGGAP1, integrin alpha FG-GAP repeat containing 2, integrin α FG-GAP repeat containing 2, KICS3, LOC100507424, MDS028, RGD1311944 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITFG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ciliary BBSome complex subunit 2, middle region
- Integrin-alpha FG-GAP repeat-containing protein 2
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi Apparatus
- cytosol
- lysosome membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITFG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germinal center B cell differentiation
- cellular response to amino acid starvation
- cellular response to glucose starvation
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- Golgi apparatus
- lysosomal membrane
- nucleoplasm