MLF1 Gene Summary [Human]
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | MLF1 |
| Official Name | myeloid leukemia factor 1 [Source:HGNC Symbol;Acc:HGNC:7125] |
| Ensembl ID | ENSG00000178053 |
| Bio databases IDs | |
| Aliases | myeloid leukemia factor 1 |
| Synonyms | HLS7, myeloid leukaemia factor 1, myeloid leukemia factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MLF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- protein domain specific binding
- Myelodysplasia-myeloid leukemia factor 1-interacting protein
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Ullrich congenital muscular dystrophy
- organismal death
- amyotrophic lateral sclerosis
- Huntington disease
role in cell
- expression in
- apoptosis
- proliferation
- growth
- phosphorylation in
- differentiation
- invasion by
- maturation
- cell cycle progression
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- motile cilia
- non-motile cilium
- Cytoplasm
- cilia
- perinuclear region
- basal bodies
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MLF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- myeloid progenitor cell differentiation
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cilium basal body
- cilium
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein domain specific binding
- protein binding