C1QTNF2 Gene Summary [Human]
Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in regulation of lipid metabolic process. Predicted to act upstream of or within positive regulation of MAPK cascade; positive regulation of glucose import; and positive regulation of small molecule metabolic process. Predicted to be located in extracellular space. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | C1QTNF2 |
| Official Name | C1q and TNF related 2 [Source:HGNC Symbol;Acc:HGNC:14325] |
| Ensembl ID | ENSG00000145861 |
| Bio databases IDs | |
| Aliases | C1q and TNF related 2 |
| Synonyms | 1810033K05RIK, Adih, C1q and TNF related 2, C1q and tumor necrosis factor related protein 2, C1q and tumour necrosis factor related protein 2, Complement-c1q tnf-related protein 2 homolog, CTRP2, RGD1561041, zacrp2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human C1QTNF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Collagen triple helix repeat (20 copies)
- protein binding
- receptor binding
- identical protein binding
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- rotator cuff injury
regulates
- PKA
- ERK1/2
- triacylglycerol
- D-glucose
- cholesterol
- HDL/cholesterol
- oxygen
- MGLL
- LDL/cholesterol
- 18:2(9Z,12Z)/18:2(9Z,12Z) phosphatidylethanolamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human C1QTNF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding