OTUD3 Gene Summary [Human]
Enables thiol-dependent deubiquitinase. Acts upstream of or within negative regulation of protein kinase B signaling; protein deubiquitination; and protein stabilization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | OTUD3 |
| Official Name | OTU deubiquitinase 3 [Source:HGNC Symbol;Acc:HGNC:29038] |
| Ensembl ID | ENSG00000169914 |
| Bio databases IDs | |
| Aliases | OTU deubiquitinase 3 |
| Synonyms | 3110030K17RIK, DUBA4, OTU deubiquitinase 3, OTU domain containing 3, RGD1560468 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OTUD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ovarian tumor domain
- peptidase
- ubiquitin-specific protease
- protein binding
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- organismal death
- ulcerative colitis
- inflammatory bowel disease
- liver cancer
- breast cancer
- metastasis
- advanced cancer
- tumorigenesis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
regulated by
- OTUD3
- nicotine
role in cell
- expression in
- phosphorylation in
- proliferation
- growth
- degradation in
- ubiquitination in
- binding in
- deubiquitination in
- polyubiquitination in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OTUD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked deubiquitination
- cellular response to nutrient levels
- proteolysis
- protein K6-linked deubiquitination
- protein stabilization
- protein K48-linked deubiquitination
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding