TREML2 Gene Summary [Human]
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | TREML2 |
| Official Name | triggering receptor expressed on myeloid cells like 2 [Source:HGNC Symbol;Acc:HGNC:21092] |
| Ensembl ID | ENSG00000112195 |
| Bio databases IDs | |
| Aliases | triggering receptor expressed on myeloid cells like 2, TREM-like transcript 2 |
| Synonyms | AC241601.3, AW049306, C6ORF76, dJ238O23.1, Gm750, LOC682922, TLT-2, triggering receptor expressed on myeloid cells-like 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TREML2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoglobulin domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetic nephropathy
- Alzheimer disease
regulates
- reactive oxygen species
role in cell
- production in
- activation
- phagocytosis
- degranulation
- chemotaxis
- engulfment
- engulfment by
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TREML2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell activation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity