Treml2 Gene Summary [Mouse]
Predicted to enable signaling receptor activity. Predicted to be involved in T cell activation. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Orthologous to human TREML2 (triggering receptor expressed on myeloid cells like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Treml2 |
| Official Name | triggering receptor expressed on myeloid cells-like 2 [Source:MGI Symbol;Acc:MGI:2147038] |
| Ensembl ID | ENSMUSG00000071068 |
| Bio databases IDs | |
| Aliases | triggering receptor expressed on myeloid cells-like 2 |
| Synonyms | AC241601.3, AW049306, C6ORF76, dJ238O23.1, Gm750, LOC682922, TLT-2, triggering receptor expressed on myeloid cells-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Treml2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoglobulin domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetic nephropathy
- Alzheimer disease
regulates
- reactive oxygen species
role in cell
- production in
- activation
- phagocytosis
- degranulation
- chemotaxis
- engulfment
- engulfment by
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Treml2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell activation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity