NUDT12 Gene Summary [Human]
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | NUDT12 |
| Official Name | nudix hydrolase 12 [Source:HGNC Symbol;Acc:HGNC:18826] |
| Ensembl ID | ENSG00000112874 |
| Bio databases IDs | |
| Aliases | nudix hydrolase 12, nucleoside diphosphate linked moiety X-type motif 12 |
| Synonyms | 0610016O18RIK, nudix hydrolase 12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUDT12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- nudix-type nucleoside diphosphatase, YffH/AdpP family
- Ankyrin repeats (3 copies)
- protein binding
- enzyme
- magnesium ion binding
- 5' phosphomonoester producing endoribonuclease
- Ankyrin repeat
- NAD+ diphosphatase
- NADH pyrophosphatase-like rudimentary NUDIX domain
- zinc ion binding
- NUDIX domain
- pyrophosphatase
- nucleotide diphosphatase
- phosphatase
- NUDIX hydrolase superfamily
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Nucleus
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUDT12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- circadian regulation of gene expression
- NADH metabolic process
- NAD biosynthesis via nicotinamide riboside salvage pathway
- mRNA catabolic process
- NAD catabolic process
- NADP catabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- nucleus
- cytoplasm
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- NAD+ diphosphatase activity
- zinc ion binding
- protein binding
- NADH pyrophosphatase activity