Nudt12 Gene Summary [Mouse]
Enables RNA NAD-cap (NMN-forming) hydrolase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in NAD-cap decapping; circadian regulation of gene expression; and mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in peroxisome. Is expressed in eye. Orthologous to human NUDT12 (nudix hydrolase 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt12 |
| Official Name | nudix (nucleoside diphosphate linked moiety X)-type motif 12 [Source:MGI Symbol;Acc:MGI:1915243] |
| Ensembl ID | ENSMUSG00000024228 |
| Bio databases IDs | |
| Aliases | nudix (nucleoside diphosphate linked moiety X)-type motif 12 |
| Synonyms | 0610016O18RIK, nudix hydrolase 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- nudix-type nucleoside diphosphatase, YffH/AdpP family
- Ankyrin repeats (3 copies)
- protein binding
- enzyme
- magnesium ion binding
- 5' phosphomonoester producing endoribonuclease
- Ankyrin repeat
- NAD+ diphosphatase
- NADH pyrophosphatase-like rudimentary NUDIX domain
- zinc ion binding
- NUDIX domain
- pyrophosphatase
- nucleotide diphosphatase
- phosphatase
- NUDIX hydrolase superfamily
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Nucleus
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- circadian regulation of gene expression
- NADH metabolic process
- NAD biosynthesis via nicotinamide riboside salvage pathway
- mRNA catabolic process
- NAD catabolic process
- NADP catabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- nucleus
- cytoplasm
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- NAD+ diphosphatase activity
- zinc ion binding
- protein binding
- NADH pyrophosphatase activity