FKBP15 Gene Summary [Human]
Predicted to enable actin binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in endocytosis and protein peptidyl-prolyl isomerization. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FKBP15 |
| Official Name | FKBP prolyl isomerase family member 15 [Source:HGNC Symbol;Acc:HGNC:23397] |
| Ensembl ID | ENSG00000119321 |
| Bio databases IDs | |
| Aliases | FKBP prolyl isomerase family member 15, protein phosphatase 1, regulatory subunit 76, WASP and FKBP-like protein |
| Synonyms | BB131447,C430014M02Rik,FK506 binding protein 15,FKBO133,FKBP-133,FKBP prolyl isomerase family member 15,KIAA0674,LOC102556352,mKIAA0674,PPP1R76,RGD1304816 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FKBP15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nuf2, DHR10-like domain
- Putative cell-wall binding lipoprotein
- Autophagy protein 16 (ATG16)
- Centrosomal colon cancer autoantigen protein family
- enzyme
- Bin/Amphiphysin/Rvs domain
- Laminin Domain I
- FKBP-type peptidyl-prolyl cis-trans isomerase
- STAT_CCD
- Family with sequence similarity 184, A and B
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- SPEC
- Salt tolerance down-regulator
- Domain of unknown function (DUF4515)
- TPR/MLP1/MLP2-like protein
- PspA/IM30 family
- Tropomyosin like
- Hyaluronan mediated motility receptor N-terminal
- SWI5-dependent HO expression protein 3
- Pleckstrin homology-like domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- PLC-beta C terminal
- TolA protein
- Synaptonemal complex central element protein 1
- Mechanosensitive ion channel porin domain
- MAP7 (E-MAP-115) family
- Trichohyalin-plectin-homology domain
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- BAR domain
- Apolipoprotein A1/A4/E domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- actin cytoskeleton
- endosomes
- growth cone
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FKBP15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endocytosis
Cellular Component
Where in the cell the gene product is active
- growth cone
- early endosome
- membrane
- actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- actin binding