FOXP1 Gene Summary [Human]
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FOXP1 |
| Official Name | forkhead box P1 [Source:HGNC Symbol;Acc:HGNC:3823] |
| Ensembl ID | ENSG00000114861 |
| Bio databases IDs | |
| Aliases | forkhead box P1, fork head-related protein like B, glutamine-rich factor 1, PAX5/FOXP1 fusion protein |
| Synonyms | 12CC4, 3110052D19RIK, 4932443N09Rik, AW494214, circFOXP1, forkhead box P1, hFKH1B, HSPC215, MFH, QRF-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- FH_FOX
- nucleic acid binding
- androgen receptor binding
- transcription factor binding
- leucine zipper domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- FOXP coiled-coil domain
- double-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- vitiligo
- lung adenocarcinoma formation
- squamous cell cancer
- neoplasia
- epithelial basal cell carcinoma
- metastasis
- skin neoplasia
- lymphomagenesis
role in cell
- expression in
- transformation
- growth
- binding in
- proliferation
- number
- differentiation
- production in
- migration
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial cell activation
- osteoclast development
- negative regulation of cell growth involved in cardiac muscle cell development
- striatum development
- macrophage activation
- negative regulation of androgen receptor signaling pathway
- monocyte activation
- positive regulation of smooth muscle cell proliferation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- cellular response to tumor necrosis factor
- response to testosterone stimulus
- positive regulation of interleukin-21 production
- positive regulation of endothelial cell migration
- regulation of tumor necrosis factor production
- regulation of monocyte differentiation
- response to DNA damage stimulus
- regulation of defense response to bacterium
- regulation of transcription from RNA polymerase II promoter
- osteoclast differentiation
- positive regulation of B cell receptor signaling pathway
- negative regulation of gene expression
- negative regulation of B cell apoptotic process
- regulation of gene expression
- regulation of inflammatory response
- response to lipopolysaccharide
- regulation of chemokine (C-X-C motif) ligand 2 production
- regulation of interleukin-1 beta production
- regulation of interleukin-12 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- core promoter sequence-specific DNA binding
- identical protein binding
- protein binding
- androgen receptor binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity