NEU2 Gene Summary [Human]
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NEU2 |
| Official Name | neuraminidase 2 [Source:HGNC Symbol;Acc:HGNC:7759] |
| Ensembl ID | ENSG00000115488 |
| Bio databases IDs | |
| Aliases | neuraminidase 2, N-acetyl-alpha-neuraminidase 2 |
| Synonyms | cytosolic sialidase, MBS, MSS, MTS, neuraminidase 2, SIAL2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEU2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sialidases/neuraminidases
- Exo-alpha-sialidase
- enzyme
- protein binding
- BNR repeat-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- liver cancer
- prostate cancer
- placental cancer
- brain cancer
- renal cancer
role in cell
- differentiation
- proliferation
- apoptosis
- growth
- killing
- binding in
- aggregation
- masking in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEU2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- glycosphingolipid catabolic process
- oligosaccharide catabolic process
- ganglioside catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- lysosome
Molecular Function
What the gene product does at the molecular level
- exo-alpha-(2->6)-sialidase activity
- protein binding
- exo-alpha-(2->8)-sialidase activity
- exo-alpha-sialidase activity
- exo-alpha-(2->3)-sialidase activity