CD33 Gene Summary [Human]
Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CD33 |
| Official Name | CD33 molecule [Source:HGNC Symbol;Acc:HGNC:1659] |
| Ensembl ID | ENSG00000105383 |
| Bio databases IDs | |
| Aliases | CD33 molecule, sialic acid binding Ig-like lectin 3 |
| Synonyms | CD33 ANTIGEN, CD33 molecule, CD33rSiglec, gp67, p67, SIGLEC-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- protein phosphatase binding
- ectodomain
- protein binding
- protein tyrosine phosphatase activator
- binding protein
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin like
- cytosolic tail domain
- membrane-proximal domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- de novo myelodysplastic syndrome
- favorable-risk acute myeloid leukemia
- acute myeloid leukemia
- extramedullary acute myeloid leukemia
- favorable-risk core binding factor acute myeloid leukemia
- Alzheimer disease
- de novo acute myeloid leukemia
- relapsed acute myeloid leukemia
- myelodysplastic syndrome
role in cell
- apoptosis
- survival
- production in
- phosphorylation in
- expression in
- proliferation
- activation
- differentiation
- binding in
- deposition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- endosomes
- Golgi Apparatus
- tertiary granule membrane
- specific granule membrane
- cytosol
- plasma membrane extracellular face
- nucleoplasm
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response-inhibiting signal transduction
- signal transduction
- negative regulation of cell proliferation
- negative regulation of interleukin-8 production
- negative regulation of interleukin-1 beta production
- cell-cell signaling
- Fc-gamma receptor signaling pathway
- cell adhesion
- positive regulation of protein secretion
- negative regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- peroxisome
- external side of plasma membrane
- Golgi apparatus
- plasma membrane
- tertiary granule membrane
- nucleoplasm
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein tyrosine phosphatase activator activity
- protein phosphatase binding
- protein binding
- signaling receptor activity
- sialic acid binding
- carbohydrate binding