PRKAG3 Gene Summary [Human]
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRKAG3 |
| Official Name | protein kinase AMP-activated non-catalytic subunit gamma 3 [Source:HGNC Symbol;Acc:HGNC:9387] |
| Ensembl ID | ENSG00000115592 |
| Bio databases IDs | |
| Aliases | protein kinase AMP-activated non-catalytic subunit gamma 3 |
| Synonyms | Amkg3, AMPK, AMPKG3, AMPKg3L, AMPKg3S, Ampk gamma3, protein kinase, AMP-activated, gamma 3 non-catalytic subunit, protein kinase AMP-activated non-catalytic subunit gamma 3, protein kinase AMP-activated non-catalytic subunit γ 3, protein kinase, AMP-activated, γ 3 non-catalytic subunit, SMGMQTL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKAG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- CBS_pair_SF
- Domain in cystathionine beta-synthase and other proteins
- AMP binding
- protein kinase binding
- CBS domain
- protein kinase regulator
- protein binding
- SNF1A/AMP-activated protein kinase
Pathways
Biological processes and signaling networks where the PRKAG3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Mitochondrial Dysfunction
- mTOR Signaling
- Osteoarthritis Pathway
- PPARα/RXRα Activation
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
role in cell
- cell cycle progression
- signal transduction in
- glycolysis in
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKAG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity involved in regulation of muscle adaptation
- glycogen biosynthetic process
- cellular response to nutrient levels
- glycolysis
- regulation of catalytic activity
- protein phosphorylation
- fatty acid biosynthetic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- cytosol
- AMP-activated protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- AMP binding
- protein binding
- AMP-activated protein kinase activity
- protein kinase regulator activity