DHRS12 Gene Summary [Human]
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DHRS12 |
| Official Name | dehydrogenase/reductase 12 [Source:HGNC Symbol;Acc:HGNC:25832] |
| Ensembl ID | ENSG00000102796 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase 12, short chain dehydrogenase/reductase family 40C, member 1 |
| Synonyms | dehydrogenase/reductase 12, FLJ13639, SDR40C1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHRS12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- sepiapterin reductase
- short chain dehydrogenase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHRS12 gene, providing context for its role in the cell.
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity