IL31RA Gene Summary [Human]
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | IL31RA |
| Official Name | interleukin 31 receptor A [Source:HGNC Symbol;Acc:HGNC:18969] |
| Ensembl ID | ENSG00000164509 |
| Bio databases IDs | |
| Aliases | interleukin 31 receptor A |
| Synonyms | CRL, CRL3, GLM-R, GPL, hGLM-R, interleukin 31 receptor A, LOC686582, NR10, PLCA2, PRO21384, zcytoR17 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL31RA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytokine binding
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- Fibronectin type 3 domain
- cytokine receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IL31RA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prurigo nodularis
- systemic sclerosis
- severe asthma
- atopic dermatitis
- airway hyperresponsiveness
- primary localized cutaneous amyloidosis type 2
- chronic atopic dermatitis
- hypoplasia
- infection by parasite
role in cell
- differentiation
- proliferation
- expression in
- phosphorylation in
- number
- function
- abnormal morphology
- signaling in
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL31RA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of tyrosine phosphorylation of STAT protein
- defense response
- glandular epithelial cell differentiation
- JAK-STAT cascade
- MAPK cascade
- negative regulation of macrophage activation
- acute inflammatory response to antigenic stimulus
- positive regulation of transcription, DNA-dependent
- cytokine-mediated signaling pathway
- negative regulation of apoptotic process
- homeostatic process
- monocyte differentiation
- macrophage differentiation
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- membrane
- external side of plasma membrane
- receptor complex
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- transcription coactivator activity
- cytokine binding
- cytokine receptor activity