TTF2 Gene Summary [Human]
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TTF2 |
| Official Name | transcription termination factor 2 [Source:HGNC Symbol;Acc:HGNC:12398] |
| Ensembl ID | ENSG00000116830 |
| Bio databases IDs | |
| Aliases | transcription termination factor 2, zinc finger, GRF-type containing 6, transcription release factor 2 |
| Synonyms | 4632434F22Rik, 8030447N19, F2, HuF2, transcription termination factor 2, transcription termination factor, RNA polymerase II, ZGRF6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- helicase superfamily c-terminal domain
- SNF2-related domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- GRF zinc finger
- protein binding
- DEAD-like helicases superfamily
- DNA dependent ATPase
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- RNA splicing
- chromatin remodeling
- transcription termination, DNA-dependent
- mRNA processing
- termination of RNA polymerase II transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription elongation factor complex
- cytosol
- spliceosomal complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- DNA-dependent ATPase activity
- zinc ion binding
- protein binding
- helicase activity
- hydrolase activity