POLR2M Gene Summary [Human]
This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]
Details
| Type | Protein Coding |
| Official Symbol | POLR2M |
| Official Name | RNA polymerase II subunit M [Source:HGNC Symbol;Acc:HGNC:14862] |
| Ensembl ID | ENSG00000255529 |
| Bio databases IDs | |
| Aliases | RNA polymerase II subunit M |
| Synonyms | D9Wsu138e, GCOM1, Gdown, Gdown1, Glurr, GRINL1A, mKIAA4185, polymerase (RNA) II (DNA directed) polypeptide M, RNA polymerase II subunit M |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2M often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative GRINL1B complex locus protein 2
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear envelope
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2M gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maintenance of ER location
- intracellular signal transduction
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- DNA-directed RNA polymerase II, holoenzyme
- I band
- neuronal cell body
- intracellular
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- transcription elongation regulator activity
- RNA polymerase II core binding