DCLRE1B Gene Summary [Human]
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | DCLRE1B |
| Official Name | DNA cross-link repair 1B [Source:HGNC Symbol;Acc:HGNC:17641] |
| Ensembl ID | ENSG00000118655 |
| Bio databases IDs | |
| Aliases | DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae) |
| Synonyms | APOLLO, DKCB8, DNA cross-link repair 1B, mSNM1B, SNM1B, SNMIB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCLRE1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metallo-beta-lactamase superfamily
- 5'-3' exonuclease
- binding protein
- beta-lactamase
- DNA repair metallo-beta-lactamase
- protein homodimerization
- enzyme
- protein binding
- metallo-hydrolase-like_MBL-fold
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- non-melanoma skin cancer
- cardiovascular disorder
- Fanconi anemia, group C
- autosomal recessive dyskeratosis congenita type 8
- myocardial infarction
- breast carcinoma
- insulin-dependent diabetes mellitus
- cutaneous melanoma
- cutaneous melanoma cancer
regulates
- leading strand of DNA
role in cell
- cell death
- hyperresection
- formation in
- cohesion in
- fusion in
- fusion
- cohesion
- hyperresection in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nucleoplasm
- nuclear bodies
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCLRE1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomeric loop formation
- protection from non-homologous end joining at telomere
- telomeric 3' overhang formation
- telomere maintenance
- telomere maintenance via telomere lengthening
- telomere capping
- double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- centrosome
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-3' exonuclease activity
- protein homodimerization activity
- protein binding
- 5'-3' exodeoxyribonuclease activity
- damaged DNA binding
- beta-lactamase activity