Dclre1b Gene Summary [Mouse]
Enables 5'-3' exonuclease activity. Involved in protection from non-homologous end joining at telomere; telomeric 3' overhang formation; and telomeric loop formation. Located in chromosome, telomeric region. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in dyskeratosis congenita. Orthologous to human DCLRE1B (DNA cross-link repair 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dclre1b |
| Official Name | DNA cross-link repair 1B [Source:MGI Symbol;Acc:MGI:2156057] |
| Ensembl ID | ENSMUSG00000027845 |
| Bio databases IDs | |
| Aliases | DNA cross-link repair 1B |
| Synonyms | APOLLO, DKCB8, DNA cross-link repair 1B, mSNM1B, SNM1B, SNMIB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dclre1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metallo-beta-lactamase superfamily
- 5'-3' exonuclease
- binding protein
- beta-lactamase
- DNA repair metallo-beta-lactamase
- protein homodimerization
- enzyme
- protein binding
- metallo-hydrolase-like_MBL-fold
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- non-melanoma skin cancer
- cardiovascular disorder
- Fanconi anemia, group C
- autosomal recessive dyskeratosis congenita type 8
- myocardial infarction
- breast carcinoma
- insulin-dependent diabetes mellitus
- cutaneous melanoma
- cutaneous melanoma cancer
regulates
- leading strand of DNA
role in cell
- cell death
- hyperresection
- formation in
- cohesion in
- fusion in
- fusion
- cohesion
- hyperresection in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nucleoplasm
- nuclear bodies
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dclre1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomeric loop formation
- protection from non-homologous end joining at telomere
- telomeric 3' overhang formation
- telomere maintenance
- telomere maintenance via telomere lengthening
- telomere capping
- double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- centrosome
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-3' exonuclease activity
- protein homodimerization activity
- protein binding
- 5'-3' exodeoxyribonuclease activity
- damaged DNA binding
- beta-lactamase activity