DCAF1 Gene Summary [Human]
Enables estrogen receptor binding activity and histone kinase activity (H2A-T120 specific). Involved in cell competition in a multicellular organism; histone H2A-T120 phosphorylation; and negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DCAF1 |
| Official Name | DDB1 and CUL4 associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30911] |
| Ensembl ID | ENSG00000145041 |
| Bio databases IDs | |
| Aliases | DDB1 and CUL4 associated factor 1 |
| Synonyms | B930007L02RIK, DDB1 and CUL4 associated factor 1, mKIAA0800, RGD1305176, RIP, VPRBP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCAF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- protein kinase
- protein binding activity, bridging
- WD40
- protein binding
- estrogen receptor binding
- enzyme
- acidic domain
- LisH
- DDB1-interaction domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- organismal death
- schizophrenia
- asthma
- allergic rhinitis
- allergy
- respiratory disorder
- androgenic alopecia
- high-grade serous ovarian cancer
- infection by HIV-1
role in cell
- apoptosis
- proliferation
- activation in
- expression in
- production in
- phosphorylation in
- accumulation in
- growth
- binding in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCAF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- V(D)J recombination
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- cell competition in a multicellular organism
- B cell differentiation
- positive regulation of protein catabolic process
- post-translational protein modification
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- signalosome
- CUL4 RING ubiquitin ligase complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- estrogen receptor binding