ADAM10 Gene Summary [Human]
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | ADAM10 |
| Official Name | ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188] |
| Ensembl ID | ENSG00000137845 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 10 |
| Synonyms | 1700031C13Rik, AD10, AD18, ADAM metallopeptidase domain 10, a disintegrin and metallopeptidase domain 10, CD156c, CDw156, DISINTEGRIN-METALLOPROTEASE, HsT18717, kuz, kuzbanian, MADM, RAK, RGD1566370, α Secretase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADAM10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- protein kinase binding
- metalloexopeptidase
- dipeptidase
- metalloprotease domain
- peptidase
- kinase-like domain
- MLF1 binding domain
- protein binding
- disintergrin domain
- metallopeptidase
- ZnMc
- endopeptidase
- cytoplasmic domain
- Metallo-peptidase family M12B Reprolysin-like
- stalk region
- protein homodimerization
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- pro domain
- cysteine rich domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the ADAM10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal neoplasm
- weight loss
- osteoarthritis
- colon cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- squamous cell cancer
- leukemia
role in cell
- molecular cleavage in
- expression in
- growth
- motility
- quantity
- apoptosis
- formation
- phosphorylation in
- activation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- tetraspanin-enriched microdomain
- glutaminergic synapse
- intracellular membrane-bounded organelle
- extracellular vesicles
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- centrosome
- Golgi Apparatus
- cell-cell contacts
- tertiary granule membrane
- specific granule membrane
- reticular perinuclear compartment
- endoplasmic reticulum lumen
- postsynaptic membrane
- synaptic membrane
- Golgi membrane
- trans Golgi network
- dendritic spines
- synaptic vesicles
- perikaryon
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADAM10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amyloid precursor protein catabolic process
- epidermal growth factor receptor ligand maturation
- adherens junction organization
- cochlea development
- extracellular matrix disassembly
- negative regulation of cell adhesion
- regulation of Notch signaling pathway
- positive regulation of cell proliferation
- cell-cell signaling
- pore complex assembly
- protein phosphorylation
- monocyte activation
- negative regulation of gene expression
- integrin-mediated signaling pathway
- positive regulation of cell growth
- Notch signaling pathway
- membrane protein ectodomain proteolysis
- in utero embryonic development
- constitutive protein ectodomain proteolysis
- positive regulation of T cell chemotaxis
- protein processing
- response to tumor necrosis factor
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- pore complex
- Golgi apparatus
- Golgi membrane
- synaptic membrane
- Golgi-associated vesicle
- plasma membrane
- tetraspanin-enriched microdomain
- cell surface
- endoplasmic reticulum lumen
- nucleus
- dendrite
- adherens junction
- extracellular vesicular exosome
- focal adhesion
- perinuclear endoplasmic reticulum
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- clathrin-coated vesicle
- tertiary granule membrane
- axon
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein homodimerization activity
- endopeptidase activity
- integrin binding
- metalloendopeptidase activity
- receptor binding
- metallopeptidase activity
- protein binding
- metallodipeptidase activity
- metal ion binding
- SH3 domain binding
- binding, bridging