GOT1 Gene Summary [Human]
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GOT1 |
| Official Name | glutamic-oxaloacetic transaminase 1 [Source:HGNC Symbol;Acc:HGNC:4432] |
| Ensembl ID | ENSG00000120053 |
| Bio databases IDs | |
| Aliases | glutamic-oxaloacetic transaminase 1, aspartate aminotransferase 1, aspartate transaminase 1, glutamate oxaloacetate transaminase 1 |
| Synonyms | AAT1, ASAT, Aspat, AST, AST1, ASTQTL1, cAspAT, CAT, cCAT, Cytosolic Aspartate Aminotransferase, Gaspat, GIG18, Glutamate oxaloacetate transaminase 1, soluble, GLUTAMIC OXALOACETIC TRANSAMINASE 1, glutamic-oxaloacetic transaminase 1, soluble, SGOT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GOT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylserine decarboxylase
- cysteine transaminase
- binding protein
- aspartate transaminase
- AAT_I
- enzyme
- Aminotransferase class I and II
Pathways
Biological processes and signaling networks where the GOT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- nonalcoholic steatohepatitis
- idiopathic scoliosis
- psoriasis
- peripheral arterial disease
- glioblastoma
- glioblastoma cancer
- liver cancer
- hearing loss
regulates
- L-aspartic acid
- L-glutamic acid
- fatty acid
- oxalacetic acid
- dicarboxylic acid
- glycerol
- collagen
role in cell
- apoptosis
- proliferation
- colony formation
- response by
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cholesterol-rich microdomain
- Nucleus
- Mitochondria
- cytosol
- synaptic vesicles
- photoreceptor outer segments
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GOT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- fatty acid homeostasis
- aspartate metabolic process
- glycerol biosynthetic process
- aspartate biosynthetic process
- 2-oxoglutarate metabolic process
- aspartate catabolic process
- cellular response to insulin stimulus
- oxaloacetate metabolic process
- glutamate metabolic process
- Notch signaling pathway
- glutamate catabolic process to 2-oxoglutarate
- glutamate catabolic process to aspartate
- response to glucocorticoid stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- phosphatidylserine decarboxylase activity
- L-aspartate:2-oxoglutarate aminotransferase activity
- L-cysteine:2-oxoglutarate aminotransferase activity