JUP
JUP Gene Summary
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | JUP |
| Official Name | junction plakoglobin [Source:HGNC Symbol;Acc:HGNC:6207] |
| Ensembl ID | ENSG00000173801 |
| Bio databases IDs | |
| Aliases | junction plakoglobin, desmosomal protein 3 |
| Synonyms | CTNNG,CTNN γ,D930025P04Rik,DP3,DPIII,gamma-CATENIN,junction plakoglobin,PDGB,PG,PKGB,Plakoglobin,γ-CATENIN |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- alpha-catenin binding
- protein kinase binding
- cell adhesion molecule binding
- protein phosphatase binding
- protein binding activity, bridging
- protein binding
- head domain
- cytoskeletal adaptor
- N-cadherin binding domain
- binding protein
- alpha catenin-binding domain
- Armadillo/beta-catenin-like repeats
- protein homodimerization
- cadherin binding
- tail domain
- CTNNAbd_CTNNB1-like
Pathways
Biological processes and signaling networks where the JUP gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- MUC1
- EGFR
- GOT1
- PDE4DIP
- alpha catenin
- CDH8
- KPLCE
- CREBBP
- PSEN1
disease
- metastasis
- epithelial cancer
- Naxos disease
- melanoma
- melanoma cancer
- arrhythmogenic right ventricular dysplasia familial 12
- atrial thrombosis
- colorectal cancer
- arrhythmogenic right ventricular cardiomyopathy
- palmoplantar keratoderma
regulated by
- EGF
- CASR
- trichostatin A
- HIF1A
- RARA
- PML
- PDGFR
- HeLa cells
- MUC1
- epigallocatechin-gallate
regulates
- MYC
- ERK
- AKT
- CASP3
- PI3K (complex)
- PIK3R1
- CTNNB1
- AXIN2
- CATNB
- reporter gene
role in cell
- expression in
- apoptosis
- proliferation
- survival
- clustering
- migration
- growth
- transformation
- differentiation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- nuclear fraction
- detergent-insoluble fractions
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- apicolateral membrane
- cornified envelope
- cell junction
- secretory granule lumen
- ficolin-1-rich granule lumen
- cytoskeleton
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- perinuclear region
- intracellular membranes
- cellular membrane
- actin cytoskeleton
- Nucleus
- intermediate filaments
- myofilaments
- intercellular junctions
- desmosomes
- cell-cell contacts
- cytosol
- cytoplasmic face of plasma membrane
- endoplasmic reticulum buds
- caveolar membranes
- apical membrane
- basolateral membrane
- lateral plasma membrane
- intercalated disks
- Z line
- anchoring junction
- junctional complexes
- zonula adherens
- lateral cell-cell contacts
- microsomal membrane
- cell-cell adherens junctions
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the JUP gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of blood vessel endothelial cell migration
- positive regulation of protein import into nucleus
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- skin development
- regulation of cell proliferation
- positive regulation of angiogenesis
- detection of mechanical stimulus
- desmosome assembly
- cellular response to indole-3-methanol
- positive regulation of cell-matrix adhesion
- canonical Wnt receptor signaling pathway
- regulation of heart rate by cardiac conduction
- cell migration
- bundle of His cell-Purkinje myocyte adhesion involved in cell communication
- protein localization in plasma membrane
- endothelial cell-cell adhesion
CELLULAR COMPONENT
Where in the cell the gene product is active
- specific granule lumen
- intermediate filament
- extracellular region
- plasma membrane
- internal side of plasma membrane
- Z disc
- nucleus
- adherens junction
- cornified envelope
- extracellular vesicular exosome
- cytoskeleton
- cell-cell junction
- focal adhesion
- cytoplasm
- zonula adherens
- protein-DNA complex
- cytosol
- intercalated disc
- catenin complex
- desmosome
- hemidesmosome
- gamma-catenin-TCF7L2 complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- alpha-catenin binding
- ligand-dependent nuclear receptor binding
- protein binding
- protein phosphatase binding
- protein homodimerization activity
- transcription coactivator activity
- cadherin binding
- cell adhesion molecule binding
- structural molecule activity
- cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication