S100P Gene Summary [Human]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | S100P |
| Official Name | S100 calcium binding protein P [Source:HGNC Symbol;Acc:HGNC:10504] |
| Ensembl ID | ENSG00000163993 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein P |
| Synonyms | AC169036.1, Gm40318, MIG9, PLACENTAL CALCIUM binding, S100 calcium binding protein P, S100 calcium binding protein P pseudogene |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S100P often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- S-100/ICaBP type calcium binding domain
- calcium ion binding
- protein homodimerization
- EFh
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pruritus
- severe acute respiratory syndrome
- ischemic stroke
- lung adenocarcinoma
- lung adenocarcinoma formation
- non-small cell lung cancer
- tumorigenesis
- metastatic colorectal cancer
- diabetes mellitus
- psoriasis
role in cell
- cell viability
- survival
- cell death
- proliferation
- migration
- adhesion
- invasion
- demethylation in
- S phase
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- cell surface
- Extracellular Space
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S100P gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- nucleus
- extracellular vesicular exosome
- cytoplasm
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- transition metal ion binding
- protein binding
- protein homodimerization activity
- calcium ion binding
- cadherin binding
- calcium-dependent protein binding