CENPL Gene Summary [Human]
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | CENPL |
| Official Name | centromere protein L [Source:HGNC Symbol;Acc:HGNC:17879] |
| Ensembl ID | ENSG00000120334 |
| Bio databases IDs | |
| Aliases | centromere protein L |
| Synonyms | 2610300B10Rik, C1orf155, centromere protein L, dJ383J4.3, RGD1311868 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CENPL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinetochore complex Sim4 subunit Fta1
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- glioblastoma
- ovarian cancer
- breast cancer
- organismal death
- lung cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- head and neck squamous cell carcinoma
role in cell
- expression in
- proliferation
- apoptosis
- Gap 0-Gap 1 phase
- misalignment in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CENPL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding